Determinants of empiric combination antibiotic therapy for hospital associated bloodstream infections in the intensive care unit.

ABSTRACT: Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (ICUs) across 52 countries, collected between June 2019 and January 2021. The main outcome was the proportion of patients receiving ECAT for HA-BSIs. Patient and institutional factors influencing the use of ECAT were examined using Markov-Chain Monte Carlo estimation. Three quarters of patients (75.2%; n = 1810) received empiric antibiotic therapy, with ECAT used in approximately half of cases (52.5%

SUBMITTER: Kauzonas E 

PROVIDER: S-EPMC12537954 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature