Multiple sclerosis patients exhibit oral dysbiosis with decreased early colonizers and lower hypotaurine level.

ABSTRACT: Although gut microbiome dysbiosis is implicated in the pathobiology of multiple sclerosis (MS), the role of the oral microbiome (OM), the second largest microbiome, remains poorly understood. Additionally, while the salivary metabolome has been linked to other neurodegenerative diseases; its role in people with Relapsing-Remitting MS (pwRRMS), the most prevalent form of MS, is unknown. Combining shotgun metagenomics with untargeted metabolomics, we identified a reduced abundance of several early colonizing species including Streptococcus and Actinomyces in pwRRMS and an enrichment of bacteria with pathogenic potential including Fusobacterium nucleatum, Porphyromonas gingivalis, and several Prevotella species. pwRRMS had an altered metabolite profile including a decreased hypotaurine compar

SUBMITTER: Fitzjerrells RL 

PROVIDER: S-EPMC12537959 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature