Senescent fibroblasts modulate the radiation response of neighboring epithelial cells.

ABSTRACT: Radiation-induced lung injury (RILI) not only limits the therapeutic dose that can be administered during chest and thorax radiotherapy (RT), but also significantly impairs patients' health and quality of life. RT-induced senescence and the associated altered secretory profile, the senescence-associated secretory phenotype (SASP), have emerged as a central process for the development and progression of pneumonitis and pulmonary fibrosis. Among various lung cell types, the phenomenon of permanent cell cycle arrest, which is also accompanied by significant morphological changes, has been observed especially in epithelial cells. RILI arises from a complex interplay of cell types and signaling pathways, but it has not yet been clarified when which lung cell types become senescent during RT and

SUBMITTER: Buchholzki M 

PROVIDER: S-EPMC12537977 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature