Safety and efficacy of different therapeutic regimens in Egyptian adults with moderate COVID-19 infection (EVEREST): a real-world retrospective study.

ABSTRACT: This study seeks to disseminate insights from Egypt's management of COVID-19 patients by evaluating the effectiveness and safety of various treatment regimens using combined repurposed antivirals. A retrospective cohort study was conducted on 310 moderate hospitalized COVID-19 cases. Patients were divided into four treatment arms: standard care, sofosbuvir/daclatasvir (sovodak) plus ivermectin, sofosbuvir/ledipasvir (SOF/LED) plus hydroxychloroquine, and SOF/LED plus ivermectin. The study analyzed parameters such as hospitalization days, total clinical recovery percentage, and progressive CT chest changes. The median hospitalization days significantly differed in arm 1 versus arms 2 and 3 (p < 0.001 and p = 0.025, respectively). There was a difference between arms 1 and 4 in the days till

SUBMITTER: Abdel-Salam Elgohary M 

PROVIDER: S-EPMC12537978 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature