Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia.

ABSTRACT: The association between Epstein-Barr virus (EBV) DNAemia after solid organ transplantation (SOT) and posttransplant lymphoproliferative disorder (PTLD) is well described. Published data support preemptive rituximab for EBV DNAemia after bone marrow transplant. However, there are inadequate data to support any specific preemptive strategy for DNAemia after SOT. The goal of this single-center retrospective cohort study was to explore the association between posttransplant rituximab and development of PTLD in SOT recipients with EBV DNAemia. This study included 1386 patients with EBV DNAemia after SOT at Columbia University Irving Medical Center from 2008 to 2023. There were 129 patients who received rituximab for various indications (eg, organ rejection, EBV DNAemia). Across all patients, 82

SUBMITTER: Orlando EH 

PROVIDER: S-EPMC12538014 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature