Herb-based multicomponent carrier-free hydrogel with antipyretic and anti-inflammatory dual effects by regulating MAPK and NF-κB signaling pathway.

ABSTRACT: Numerous traditional Herbal medicine (THM) formulas have demonstrated their effectiveness during long-term clinical practices worldwide, offering a rich repository for the discovery of new drug and functional biomaterials. Consequently, the development of therapeutic supramolecular hydrogels based on plant-derived bioactive molecules has garnered significant attention in the field of new drug development. In this study, we developed a well-defined orally supramolecular drug derived from the classic Ma-Xing-Shi-Gan decoction (MXSGD) which has been widely used in China for the treatment of COVID-19 symptoms and acute infectious diseases. The four representative chemical components of MXSGD-pseudoephedrine, amygdalin, glycyrrhizic acid, and Ca²⁺-co-assembled into quaternary carrier

SUBMITTER: Wang P 

PROVIDER: S-EPMC12538044 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature