Obesity-induced cofilin1 pathway dysregulation: Possible molecular links between neuroinflammation, cognitive decline, and Alzheimer's disease biomarkers.

ABSTRACT: Obesity is a growing concern globally, particularly among young populations. Cofilin1, a major actin-depolymerizing factor (ADF) isoform in the CNS, acts as a stress protein that triggers neuroinflammation and correlates with the onset of Alzheimer's disease (AD). However, its role in obesity has not yet been identified. In this study, we investigated the influence of diet-induced obesity on cofilin1 dysregulation in the brain and its correlation to neurobehavioral deficiencies, neuroinflammation, synaptic dysfunction, and AD biomarkers. Male C57BL/6 mice were fed a regular diet (control) or a high-fat diet (HFD, obese) for 7 weeks to induce obesity. Our data demonstrate that the activation of cofilin1 in the hippocampus region of HFD mice brains is mediated by Slingshot homolog-1 (SSH1) o

SUBMITTER: Alsegiani AS 

PROVIDER: S-EPMC12538084 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature