Subtype-specific genetic drivers of immune evasion in breast cancer.

ABSTRACT:

Background

Immune evasion is a hallmark of cancer and a driver of therapeutic resistance. Although immunotherapy is effective in highly immunogenic cancers, its efficacy in breast cancer (BC) remains limited. We aimed to determine the prognostic relevance of immune-related gene signatures across distinct BC subtypes.

Materials and methods

We used transcriptomic and clinical data from three independent cohorts [Gene Expression Omnibus (GEO), The Cancer Genome Atlas, and GSE96058]. We analyzed 106 genes associated with the evasion of immune destruction (EID) and 182 genes involved in the evasion of killing by cytotoxic T lymphocytes (ECTL). Expression of signatures was stratified by BC subtypes. Cox regression and Kaplan-Meier curves were used to assess survival, with false di

SUBMITTER: Menyhart O 

PROVIDER: S-EPMC12538131 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature