Plasma lipidomics and fungal peptide-based community analysis identifies distinct signatures for early mortality in acute liver failure.

ABSTRACT:

Background/aims

Acute liver failure (ALF) has high mortality predominantly due to compromised immune system and increased vulnerability to bacterial and fungal infections.

Methods

Plasma lipidome and fungal peptide-based community (mycobiome) analysis were performed in discovery cohort (ALF=40, healthy=5) and validated in a validation cohort of 230 patients with ALF using high-resolution-mass-spectrometry, artificial neural network (ANN) and machine learning (ML).

Results

Untargeted lipidomics identified 2,013 lipids across 8 lipid group. 5 lipid-species-phosphatidylcholine (PC)[15:0/17:0], PC[20:1/14:1], PC[26:4/10:0], PC[32:0] and TG[4:0/10:0/23:6]-significantly differentiated ALF-NS (FC>10, P<0.05, FDR<0.01). Mycobiome alpha/beta diversity was significantly higher

SUBMITTER: Sharma N 

PROVIDER: S-EPMC12538150 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature