Patterns of lithium exposure and mortality in bipolar disorder: A population-based cohort study.

ABSTRACT:

Background

Lithium treatment is associated with reduced mortality in bipolar disorder (BD), but the role of treatment continuity remains underexplored. This study investigated the association between patterns of lithium exposure and all-cause mortality in a population-based cohort.

Methods

We analyzed electronic health records from 15,384 individuals with BD in Catalonia, Spain (2010-2019). Patients were classified as having sustained, partial/intermittent, or no lithium exposure based on annual defined daily doses (DDDs). All-cause mortality was the primary outcome. Kaplan-Meier and Cox regression analyses (adjusted for sociodemographic, clinical, and treatment-related variables) estimated hazard ratios (HRs) for mortality risk. Interaction and sensitivity analyses were con

SUBMITTER: Oliva V 

PROVIDER: S-EPMC12538171 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature