Genome-wide methylation biomarkers and biological aging in patients with bipolar disorder characterized for lithium response.

ABSTRACT:

Background

Epigenetic mechanisms might play a role in modulating susceptibility to bipolar disorder (BD) and response to lithium, the mainstay treatment for BD. Additionally, individuals with BD experience accelerated biological aging.

Methods

We compared blood DNA methylation profiles measured with EPIC v.2.0 arrays between patients with BD (33 lithium responders and 31 nonresponders) and nonpsychiatric controls (n = 32), as well as based on long-term lithium response. In addition, we compared cellular aging between these groups using epigenetic age, pace of aging, and, for the first time, transcriptional age acceleration based on bulk RNA sequencing in 93 patients and 56 controls.

Results

We identified 191 differentially methylated positions (DMPs) and 8 diff

SUBMITTER: Pisanu C 

PROVIDER: S-EPMC12538177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature