Effects of Intensive Systolic Blood Pressure Control on Kidney Outcomes in Patients With and Without CKD: A Post Hoc Analysis of SPRINT and ACCORD-BP Trials.

ABSTRACT:

Background

The effects of intensive blood pressure (BP) control on adverse kidney outcomes remain undetermined.

Methods

This post hoc analysis included the Systolic Blood Pressure Intervention Trial (SPRINT) participants and the Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD-BP) participants receiving standard glucose-lowering treatment and satisfying SPRINT eligibility criteria. The risks of kidney events between intensive (systolic BP < 120 mmHg) and standard (systolic BP < 140 mmHg) controls in participants with or without baseline chronic kidney disease (CKD) were compared using Cox proportional hazards models.

Results

A total of 10,946 participants (2724 with CKD and 8222 without CKD) were included. During the intervention and post-inter

SUBMITTER: Xu X 

PROVIDER: S-EPMC12538231 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature