Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality.

ABSTRACT:

Importance

Although suicide attempt is the most robust estimator of suicide death, few individuals who attempt it go on to die by suicide (<10%), and approximately 50% of suicide deaths occur in the absence of evidence of prior attempts. The risks are particularly poorly understood in this group.

Objective

To study underlying polygenic liabilities among suicide deaths without evidence of prior nonfatal suicidality (SD-N) compared with suicide deaths with prior suicidality (SD-S), testing prior results showing significantly lower clinical risks of neuropsychiatric traits in SD-N vs SD-S.

Design, setting, and participants

In this cohort study, polygenic scores (PGS) were computed using summary statistics from 12 published source studies, then compared across SD-N and SD

SUBMITTER: Coon H 

PROVIDER: S-EPMC12538367 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature