A systematic literature review and bayesian meta-analysis of oral vancomycin primary prophylaxis for <i>Clostridioides difficile</i> infection in stem cell transplant patients.

ABSTRACT:

Introduction

Clostridioides difficile infection (CDI) is common among patients undergoing hematopoietic stem cell transplantation (HSCT). Oral vancomycin prophylaxis may effectively prevent CDI in certain populations. We investigated the effectiveness of oral vancomycin primary prophylaxis in preventing CDI in HSCT patients.

Methods

We searched six databases from inception to March 21, 2025, for studies comparing the incidence of CDI in HSCT patients who received oral vancomycin primary prophylaxis versus those who did not. We built a Bayesian random-effects model for meta-analysis. The primary outcome was the incidence of CDI. Secondary outcomes included incidence of positive vancomycin-resistant Enterococcus cultures, blood stream infections, graft-vs-host di

SUBMITTER: Viana-Cardenas E 

PROVIDER: S-EPMC12538368 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature