County-Level Factors and Preventable Premature Liver Mortality in Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT:

Importance

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly significant cause of premature liver mortality (PLM) in the US; however, the proportion that is preventable and the upstream factors remain poorly understood.

Objective

To quantify the burden of preventable MASLD-PLM and identify county-level factors associated with its variation.

Design, setting, and participants

Ecological, cross-sectional study of publicly available mortality and county-level data from January 2011 to December 2020 for US counties with complete covariate information. MASLD-PLM was defined as liver-related deaths where MASLD was recorded as an underlying or contributing cause, among decedents aged 75 years or younger for males and 80 years or younger for f

SUBMITTER: Paik JM 

PROVIDER: S-EPMC12538370 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature