European human granulocytic anaplasmosis is caused by a subcluster of <i>Anaplasma phagocytophilum</i> Ecotype I.

ABSTRACT: Anaplasma phagocytophilum causes human granulocytic anaplasmosis. However, despite its ubiquitous presence in animals and ticks, human cases are rarely reported in Europe. We generated genetic data from A. phagocytophilum from patients and compared them with sequences from wild and domestic animals to assess the zoonotic potential of the respective genotypes. The genomic sequence of an A. phagocytophilum isolate obtained from a Slovenian patient was determined. We also sequenced a groEL-gene fragment of eight isolates from human patients from France and Poland. The A. phagocytophilum genome from the Slovenian patient was more closely related to isolates from dogs than from sheep. Using groEL-based typing, isolates from humans were found within a di

SUBMITTER: Lesiczka PM 

PROVIDER: S-EPMC12538471 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature