Effect of Visceral Adipose Tissue on Major Depressive Disorder: A Mendelian Randomisation Research.

ABSTRACT:

Aims

Visceral adipose tissue (VAT) is associated with major depressive disorder (MDD) in observational studies, but these findings are susceptible to confounding and reverse causation. This study employed a two-sample Mendelian randomisation (MR) approach to assess the causal relationship between VAT and MDD.

Methods

We selected 221 single nucleotide polymorphisms associated with VAT mass in 325,153 individuals of European ancestry from UK Biobank as instrumental variables. Summary-level genetic data for MDD (59,851 cases and 113,154 controls) were accessible from the Psychiatric Genomics Consortium database. Primary MR analysis used the inverse-variance weighted (IVW) method, with weighted median and MR-Egger approaches as sensitivity analyses. Additional tests, including M

SUBMITTER: Li X 

PROVIDER: S-EPMC12538619 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature