Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC.

ABSTRACT:

Introduction

The diverse presentations and co-pathologies of Lewy body dementia (LBD) present a diagnostic challenge. Utilizing the National Alzheimer's Coordinating Center (NACC) dataset, this study aimed to evaluate the concordance of premorbid diagnoses of LBD in individuals with autopsy-confirmed neocortical Lewy body disease.

Methods

Demographics, clinical and neuropsychological presentations, Lewy body pathology, and Alzheimer's disease (AD) co-pathology were related to clinical diagnosis.

Results

Diagnosis of LBD had high specificity but low sensitivity, with fewer than half of autopsy-confirmed cases having received an LBD diagnosis. AD was the most common misdiagnosis. Participants diagnosed with AD were more likely to be female, to have a more amnestic pheno

SUBMITTER: Goodheart AE 

PROVIDER: S-EPMC12538637 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature