Clinical Features and Outcomes of Primary Colorectal Diffuse Large B-Cell Lymphoma: A Multicenter Retrospective Study.

ABSTRACT:

Background

Primary gastrointestinal (GI) diffuse large B-cell lymphoma (DLBCL) is a rare malignancy. Given its rarity, the nature of the disease, particularly those originating in the colorectum, remains poorly defined.

Aims

This multicenter retrospective study analyzed the clinical characteristics and treatment outcomes of primary GI DLBCL, with a focus on colorectal cases.

Materials & methods

A total of 104 cases of primary GI DLBCL were retrospectively collected from three institutions (2010-2024) and classified into three groups based on the lymphoma's origin.

Results

Among 104 patients, 57.7% had gastric, 18.3% small bowel, and 24.0% colorectal DLBCL. Approximately 60% presented with limited-stage disease (Stage I-II). All patients received front-line R-CH

SUBMITTER: Lee YP 

PROVIDER: S-EPMC12538638 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature