The association of common infectious exposures with cognitive performance in community-dwelling older adults.

ABSTRACT:

Introduction

The Northern Manhattan Study (NOMAS) previously identified that a combined infectious disease exposure index correlates with impaired cognitive performance in older adults.

Methods

We extended these findings by examining the association of serological titers of five common infectious diseases (herpes simplex virus [HSV] 1 and 2, cytomegalovirus [CMV], Chlamydia pneumoniae, and Helicobacter Pylori) with domain-specific cognitive performance and incident cognitive impairment and dementia in 593 community-dwelling older adults. We performed confounder-adjusted mixed linear regression between infectious serologies and longitudinal cognitive performance.

Results

CMV and HSV-2 serologies were associated with impaired executive function, whereas C. pneumoniae se

SUBMITTER: Roberts JA 

PROVIDER: S-EPMC12538643 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature