Entwined processes in Alzheimer's disease: Brain cellular senescence and Alzheimer's disease pathology.

ABSTRACT: Alzheimer's disease (AD) is one of the most common age-related neurodegenerative diseases with severe progressive dementia. Amyloid beta (Aβ) deposition and phosphorylated tau accumulation are two typical AD pathologies, which could drive senescence in various types of brain cells. These factors interact to form an entwined vicious cycle, in which each cell could play an irreplaceable role. Thus, it is essential to stress the cause-and-effect relationship in this process and to identify the key factor leading to the vicious cycle. In this narrative review, we discuss (1) how AD pathology induces cellular senescence in different brain cell types; (2) how various accumulated senescent brain cells exacerbate AD pathology; and (3) how cellular senescence and AD pathology are entwined, reinforc

SUBMITTER: Li W 

PROVIDER: S-EPMC12538649 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature