High-Glucose Microenvironment Accelerates Malignant Progression Via O-GlcNAcylation in Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

Diabetes mellitus (DM) is a risk factor for oral squamous cell carcinoma (OSCC). O-GlcNAcylation is a specific form of glycosylation modification sensitive to glucose levels and implicated in tumour progression. However, the association between the high-glucose environment, O-GlcNAcylation, and OSCC needs further exploration.

Methods

The relationship between DM status and clinicopathological factors was analysed. The Kaplan-Meier analysis was performed to evaluate the effect of DM on OSCC prognosis. The proliferation, migration, invasion, and apoptosis of OSCC cell lines (SCC25 and CAL27) in the high-glucose microenvironment were analysed using CCK8, colony formation, wound healing, transwell assays, flow cytometry, and western blots (WB). Immunohistochemical stai

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12538696 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature