The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine.

ABSTRACT: Chromatin remodeling provides essential transcriptional regulation for all biological processes. In Caenorhabditis elegans, the chromatin remodeler LET-418, a homolog of the human Mi-2β protein, plays a critical role in regulating development, organogenesis, tissue maintenance, stress resistance and lifespan. LET-418 is part of several chromatin remodeling complexes and contributes significantly to the balance between growth and defense mechanisms, yet its target genes remain unclear. Using DNA methylation profiling, we identified genomic binding sites and associated target genes of LET-418 and its MEC-complex-specific interactor MEP-1 in the intestine. Consistent with their presence in the same complex, the two proteins shared more than half of their target genes. Functional analysis reve

SUBMITTER: Rajopadhye S 

PROVIDER: S-EPMC12538751 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature