Macrophage dynamics and the role of TREM2 at the oral mucosal barrier.

ABSTRACT:

Background

Macrophages have a critical role in mucosal barrier immunity, demonstrating dynamic phenotypes that promote and resolve inflammation. However, the regulation of this polarization is not fully understood. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoregulatory receptor expressed on macrophages. The role of TREM2 in mucosal immunity has not been previously studied. Our objective was to investigate TREM2 on macrophages during periodontal disease (PD), a chronic inflammatory condition affecting the oral mucosa.

Methods

PD was induced using a ligature method in wild-type (WT) and TREM2^-/- mice. Macrophages were isolated from oral mucosa and analyzed via flow cytometry. PD severity was assessed via quantification of bone loss and local

SUBMITTER: Leite TC 

PROVIDER: S-EPMC12538780 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature