Clinical outcomes by bone metastasis uptake pattern in differentiated thyroid cancer.

ABSTRACT:

Backgrounds

Patients with differentiated thyroid cancer (DTC) and bone metastases (BM) exhibit heterogeneous radioactive iodine (RAI) and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) uptake patterns at diagnosis. This study is aimed to evaluate clinical outcomes influenced these distinct uptake patterns.

Methods

Patients confirmed DTC with BM were involved in this study between 2006 and 2021. All patients received ¹³¹I treatment and performed ¹⁸F-FDG positron emission tomography with computed tomography (PET/CT) at diagnosis. Variables including patient's gender, age, pathology, laboratory examination, uptake pattern of bone lesions, treatment protocols, and metabolic parameters of PET/CT were analyzed for the prognosis.

Results

Among 67 e

SUBMITTER: Wang G 

PROVIDER: S-EPMC12538781 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature