Spatiotemporal transcriptomic characteristics of immune and metabolic dysregulation during mouse brain aging.

ABSTRACT:

Background

Aging and its associated neurodegenerative diseases were increasingly recognized as one of the greatest global health threats. Brain aging involved a multitude of pathological changes, including immune inflammation and metabolic dysregulation.

Methods

We systematically characterized spatiotemporal heterogeneity and dynamic gene expression profiles related to immune and metabolic dysfunction during mouse brain aging. By analyzing differentially expressed genes and conducting functional enrichment and gene set enrichment analysis, we constructed a spatiotemporal transcriptomic atlas of aging-associated metabolic and immune features. We further performed transcription factor enrichment analysis, regulatory network construction, weighted gene co-expression network ana

SUBMITTER: Qin M 

PROVIDER: S-EPMC12538783 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature