MicroRNA expression dynamics in mouse liver at different stages of Echinococcus multilocularis infection.

ABSTRACT:

Background

Alveolar echinococcosis (AE) is a globally widespread zoonotic disease caused by the larval stage of the tapeworm Echinococcus multilocularis, posing a high fatality rate and poor prognosis if not properly managed. Currently, effective vaccines or drugs for echinococcosis remain elusive. MicroRNAs (miRNAs) play crucial roles in various biological processes and are closely linked with parasite infection and pathogenicity. To date, there is limited knowledge about host miRNA profiles in E. multilocularis infection at different stages. Hence, exploring host miRNA expression patterns at different infection stages is vital for understanding miRNA transcriptional regulation mechanisms.

Methods

This study employs small RNA sequencing to depict the temporal dynamics of mi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12538786 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature