Gut microbiome alterations in IgG4-related ophthalmic disease.

ABSTRACT:

Background

This study aims to investigate the gut microbiome alterations in IgG4-related ophthalmic disease (IgG4-ROD) and explore the potential roles of serum IgE and IgG4 in this disease.

Methods

In this prospective study, we recruited a total of 34 participants, including 17 IgG4-ROD patients and 17 healthy controls (HC) from Beijing Tongren Hospital. Fecal and blood samples were collected and analyzed, including 16 S rRNA gene sequencing of fecal samples. We assessed alpha and beta diversity to identify microbial variations among IgG4-ROD and HC, IgG4+ and IgG4-, IgE + and IgE-, and hormone-treated and untreated groups. Correlation analyses between cytokines and microbial profiles were conducted to uncover novel insights into the pathogenesis of IgG4-ROD.

Results

SUBMITTER: Ren T 

PROVIDER: S-EPMC12538800 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature