Reproductive history and cardiometabolic disease: the role of endogenous estrogen exposure across the lifespan in postmenopausal women.

ABSTRACT:

Background

The association between cumulative endogenous estrogen exposure across the lifespan, especially considering reproductive events, and women's cardiometabolic health remain unclear. We aimed to examine the associations between lifetime endogenous estrogen exposure and the risks of diabetes, hypertension, and cardiovascular disease (CVD) among postmenopausal women.

Methods

We used baseline data from the Regional Ethnic Cohort Study in Northwest China. Reproductive factors were self-reported using a structured questionnaire, and surrogate indicators of estrogen exposures-reproductive lifespan, endogenous estrogen exposure, cumulative gestation duration and other proportional indicators-were calculated. Diabetes, hypertension and CVD were defined based on self-reported

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12538824 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature