Radiation- and age-related vascular dysfunction as an early indicator of cardiovascular risk: a long-term study in the ApoE^-/- mouse model of atherosclerosis.

ABSTRACT:

Background

Despite advances in radiotherapeutic techniques, radiation-induced cardiovascular diseases (CVD) remain a leading but often underrecognized cause of morbidity and mortality in cancer survivors. Radiation exposure can trigger a broad spectrum of cardiotoxic effects yet clinical awareness and strategies for managing these long-term complications remain limited. Among emerging indicators of vascular dysfunction, measures of vascular flexibility offer key biomarkers for assessing vascular compliance and cardiovascular risk.

Methods

The present study hence investigated age- and dose-dependent effects of local irradiation on vascular function of the murine Arteria saphena in C57BL/6 wild-type and atherosclerosis-prone apolipoprotein E-knockout (ApoE^-/-) mice,

SUBMITTER: Habelt B 

PROVIDER: S-EPMC12538826 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature