MED15-TFE3 rearranged renal cell carcinoma: a subtype of TFE3-rearranged renal cell carcinoma with unique clinicopathologic features and better prognosis.

ABSTRACT:

Background

MED15-TFE3 rearranged renal cell carcinoma (MED15-TFE3 rRCC) is a rare subtype of TFE3-rearranged renal cell carcinoma (TFE3 rRCC). To date, only 47 cases of MED15-TFE3 rRCC (including 2 cases from our institution) have been reported worldwide.

Methods

Using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and RNA sequencing, we aimed to identify whether TFE3 rRCC patients at our institution harbor the MED15-TFE3 gene fusion. We will perform a statistical analysis of the pathological features, imaging findings, and clinical outcomes of all published cases of MED 15-TFE rRCC.

Results

MED15-TFE3 rRCC typically has a cystic and solid (predominantly cystic) architecture. The tumor cells feature round nuclei with inconspicuous nucleoli, abu

SUBMITTER: Deng Z 

PROVIDER: S-EPMC12538908 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature