Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

ABSTRACT:

Purpose

To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.

Design

Single-center, retrospective, observational study.

Design

Single-center, retrospective, observational study.

Main outcome measures

The primary outcome was the clinical pregnancy rate (CPR).

Results

After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).

Conclusion

Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women un

SUBMITTER: Wang X 

PROVIDER: S-EPMC12538927 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature