TIGD6 in gastric cancer: exploring its prognostic value and therapeutic potential through molecular and clinical investigations.

ABSTRACT:

Background

Gastric cancer (GC) predominantly contributes to cancer mortality, with adenocarcinomas accounting for more than 95% of incidences. Early detection improves survival, but most cases are diagnosed at advanced stages due to subtle symptoms and rapid progression. The role of TIGD6 in GC is unclear.

Methods

We analyzed TIGD6 expression using TCGA data and correlated it with clinical features and outcomes in GC patients. Bioinformatics tools, including GSEA and single-cell sequencing, were used to elucidate TIGD6's role in GC. In the GC cell lines AGS and HGC-27, TIGD6 was knocked down using RNA interference, and subsequent in vitro experiments were conducted to evaluate cell proliferation, migration, and invasion capabilities.

Results

The expression of TIGD6 wa

SUBMITTER: Han Q 

PROVIDER: S-EPMC12538967 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature