Serum lactate Dehydrogenase-to-Albumin ratio in upper tract urothelial carcinoma: A promising prognostic biomarker.

ABSTRACT:

Objective

The objective of this study is to assess the predictive significance of lactate dehydrogenase-to-albumin ratio (LAR) in patients with upper tract urothelial carcinoma (UTUC) who have undergone radical nephroureterectomy (RNU).

Materials and methods

We performed a retrospective analysis on patients with UTUC at West China Hospital, covering the period from May 2003 to June 2019. The optimal cut point of LAR was determined using the X-Tile program. Relevant statistical methods included the utilization of Kaplan-Meier curves for survival estimation and the application of Cox proportional hazard model for risk evaluation. A nomogram was constructed to predict the 3-year and 5-year CSS and the predictive performance was also evaluated.

Results

A cohort of 577 pat

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12539002 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature