Biopsy proteome-based classification of T cell-mediated kidney allograft rejection.

ABSTRACT:

Background

T cell-mediated rejection (TCMR) remains a challenge in kidney transplantation. Based on a histopathological biopsy examination, patients can be classified into groups such as no rejection (NR), borderline rejection (BR; Banff category 3), and acute rejection (AR; Banff category 4). Yet, this classification is not sufficient, since for the borderline cases a number of patients may require a clinical intervention. Thus, a robust classification by biopsy proteome profiling may provide a solution.

Methods

In this work, kidney tissue from patients classified into NR, BR, and AR were subjected to MS-based proteomic profiling. Subsequently, a panel of four proteins (GNB4, PDK1, AGXT, CD73) was selected for validation by immunohistochemistry (IHC). This retrospective stu

SUBMITTER: Kania D 

PROVIDER: S-EPMC12539011 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature