BMI partially mediates the association between the non-HDL-C/HDL-C ratio and depression in obese adults.

ABSTRACT:

Background

Depression has become one of the major global public health burdens. In recent years, lipid metabolic abnormalities have garnered increasing attention as potential influencing factors. Among these, the ratio of non-high-density lipoprotein to high-density lipoprotein cholesterol (NHHR) is regarded as an integrated indicator for assessing atherosclerosis risk. Obesity, as a hallmark of metabolic dysregulation, has a complex interplay with depression. This study aimed to investigate the association between NHHR and depression among obese adults and to evaluate the mediating role of body mass index (BMI) in this relationship.

Methods

This study utilized data from the 2013-2023 National Health and Nutrition Examination Survey (NHANES), ultimately including 13,991 adul

SUBMITTER: Qiu K 

PROVIDER: S-EPMC12539016 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature