Quorum quenching by endophytic Bacillus cereus AL1: a lactonase-based anti-virulence strategy against Pseudomonas aeruginosa.

ABSTRACT:

Background

Pseudomonas aeruginosa infections are often challenging to treat due to multiple drug resistance, besides the development of biofilms and a plethora of virulence factors regulated by quorum sensing. Quorum-quenching enzymes, such as N-acyl homoserine lactonases, represent a promising anti-virulence strategy by disrupting this signaling mechanism without exerting selective pressure, leading to resistance. This study aimed to screen endophyte and epiphyte isolates for lactonase activity and evaluate their potential to inhibit virulence in Pseudomonas aeruginosa.

Results

Fifty-two bacterial isolates (42 endophyte and 10 epiphyte) were isolated from ten plants. The aiiA gene encoding lactonase enzyme was detected in 11 endophytes and one epiphyte isolate, among which

SUBMITTER: Fawzy AA 

PROVIDER: S-EPMC12539043 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature