Metabolic dynamics and stage-specific biomarkers in chronic HBV infection: a metabolomics study.

ABSTRACT:

Objective

This study was aimed to identify and investigate changes in serum metabolites across the natural progression of chronic hepatitis B (CHB) patients, discover differential metabolites and metabolic pathways in different disease phases, and provide an experimental foundation for clinical diagnosis, staging, treatment, and prognosis of CHB.

Methods

A total of 279 CHB patients hospitalized at Hunan Provincial People's Hospital from June 2020 to March 2021 were enrolled, including 47 in the immune-tolerant (IT) group, 44 in the immune-clearance (IC) group, 73 in the low-replication (LR) group, 57 in the enhanced-replication (ENH) group, 32 in the liver cirrhosis (LC) group, and 26 in the hepatocellular carcinoma (HCC) group, along with 44 healthy controls. Serum metaboli

SUBMITTER: Liu L 

PROVIDER: S-EPMC12539061 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature