HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men.

ABSTRACT:

Background

Prior research on the genetics of human longevity has identified only a few robust associations. While these studies highlight the importance of metabolic processes for longevity, the contribution of immune genes, specifically those in the highly polymorphic human leukocyte antigen (HLA) region, remains understudied. Here, we addressed this gap by analysing the influence of HLA variation on longevity in Europeans.

Methods

We conducted an initial case-control study, comparing imputed HLA alleles from a German longevity cohort with younger controls. Associations were evaluated with logistic regression, adjusting for multiple testing and population structure. Subsequently, significant associations (adjusted P ≤ 0.05) were tested for replication in two additional popu

SUBMITTER: Mendoza-Mejia N 

PROVIDER: S-EPMC12539080 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature