Identification of Cdc45-interacting partners uncovers two Leishmania donovani proteins involved in DNA replication.

ABSTRACT:

Background

Among fatalities due to parasitic diseases, deaths due to Leishmaniases rank second only to those caused by malaria. Endemic to 90 countries, more than a billion people are at risk of Leishmania infection. While there are no vaccines against Leishmaniases, treatments are available. However, the complexities of the treatment regimens, their high costs and toxic side effects, and most importantly the emerging problem of drug resistance, have continued to thrust forward research into this parasite's cellular processes. The parasite is digenetic, reproducing by binary fission in both hosts, with DNA replication being central to the process. The absence of many conserved DNA replication proteins in Leishmania suggests the possibility of parasite-specific proteins being involv

SUBMITTER: Dashora V 

PROVIDER: S-EPMC12539117 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature