Severe Multi-organ dysfunction secondary to Shigella flexneri encephalopathy (Ekiri Syndrome): a case report and review of the literature.

ABSTRACT: Shigella infection is a major global cause of diarrhea, particularly among children in low- and middle-income countries. While most cases are self-limited, certain strains such as Shigella flexneri can lead to severe systemic complications, including encephalopathy. Among the rarest and most fatal forms is Ekiri syndrome, primarily reported in East Asian literature, characterized by fulminant neurotoxicity, high fever, seizures, and rapid progression to coma or death. In this study, we report the case of a previously healthy 14-year-old girl who presented with vomiting, diarrhea, and low-grade fever, initially treated conservatively. Her condition worsened with progressive lethargy and a generalized seizure, leading to ICU admission. Brain imaging showed diffuse cerebral edema, and her tem

SUBMITTER: Alishvandi A 

PROVIDER: S-EPMC12539137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature