Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.

ABSTRACT:

Background

Silver diamine fluoride (SDF) is a simple and non-invasive agent used to arrest early childhood caries (ECC). This study aimed to investigate potential changes to the oral microbiome in children with ECC who were treated with SDF and sodium fluoride (NaF) varnish at three different frequency regimens.

Methods

Forty-five children (n = 15 per group) with ECC were recruited from community-based dental clinics in Winnipeg, Canada into an open-label, parallel-group, randomized clinical trial testing three different treatment frequency regimens of SDF. A total of 195 carious lesions were treated with two applications of 38% SDF and 5% NaF varnish (and assessed over three study visits one month, four months, or six months apart. Dental plaque samples were collected at ea

SUBMITTER: Manerkar M 

PROVIDER: S-EPMC12539150 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature