Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses.

ABSTRACT:

Introduction

The associations between excess adiposity and endometrial cancer (EC) risk may be mediated by altered metabolic profiles. Here, we triangulated evidence from observational and Mendelian randomisation (MR) analyses to investigate the relationship between adiposity traits, circulating metabolites, and their effects on endometrial cancer.

Methods

Observational analyses were performed in UK Biobank (N cases and controls = 1,005 and 215,339, respectively). Univariable and multivariable MR analyses were performed using female-specific summary statistics for adiposity traits (GIANT consortium; N BMI and WHR = 434,793 and 281,153, respectively), circulating metabolites (UK Biobank; N = 140,768) and EC (Endometrial Cancer Association Consortium; N cases and controls = 12

SUBMITTER: Lee MA 

PROVIDER: S-EPMC12539199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature