CSE-Derived Hydrogen Sulfide Safeguards Vascular Iron Homeostasis by Coupling Ferritin Buffering to Vasoprotection.

ABSTRACT: Iron overload drives oxidative stress and vascular injury, yet the role of hydrogen sulfide (H₂S) in systemic and vascular iron regulation remains unclear. We investigated how cystathionine γ-lyase (CSE)-derived H₂S influences iron handling and vascular responses following acute iron overload. Wild-type (WT) and CSE-knockout (CSE-KO) mice received PBS, low-concentration (1×) or high-concentration (3×) iron dextran intravenously. CSE-KO mice exhibited elevated serum iron and transferrin saturation but impaired ferritin upregulation compared to WT. KO aortas showed greater iron deposition, elastin degradation, and inflammatory remodeling under high iron. Iron overload impaired phenylephrine-induced vasocontraction and H₂S-mediated vasorelaxation, with CSE-KO

SUBMITTER: Arif HM 

PROVIDER: S-EPMC12539386 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature