Homeostatic Counter-Regulation Mediates Spermidine-Induced Triacylglyceride Reduction in Drosophila melanogaster-From Phenotype to Molecular Mechanism.

ABSTRACT: The polyamines putrescine, spermidine (Spd), and spermine have essential functions in cell growth and proliferation. Previous research has unveiled a potential link between polyamine metabolism and triacylglyceride (TAG) homeostasis. In this study, we utilized Drosophila melanogaster as a model to study the impact of dietary (Spd) on body TAG stores. We found that food supplementation with 1.0 mM and 2.5 mM Spd prevented the build-up of TAG stores in female fruit flies monitored for up to 14 days post-eclosion in a dose- and time-dependent manner, without affecting their total protein content. Notably, a 7-day treatment with 2.5 mM Spd also counteracted high-sugar diet-induced obesity and accelerated the breakdown of existing TAG reserves in obese females. Mechanistic analysis revealed tha

SUBMITTER: Luersen K 

PROVIDER: S-EPMC12539389 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature