Pericardial Diffuse Large B-Cell Lymphoma Diagnosed Via Computed Tomography-Guided Biopsy.

ABSTRACT:

Background

Primary pericardial lymphomas are rare. We describe a case of pericardial diffuse large B-cell lymphoma (DLBCL) diagnosed via computed tomography (CT)-guided biopsy.

Case summary

A 57-year-old man presented with chest pain and weight loss for 1 month. Multiple diagnostic modalities revealed a pericardial mass with effusion. Pericardiocentesis was performed, and cytology suggested malignant lymphoma; however, the procedure was complicated by pneumothorax owing to mediastinal distortion from the pectus excavatum and minimal effusion. After multidisciplinary discussion, CT-guided biopsy was performed, which confirmed DLBCL. Polatuzumab vedotin, rituximab/cyclophosphamide, doxorubicin, and prednisone were initiated, resulting in tumor shrinkage.

Discussion

Earl

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC12539431 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature