Upregulation of Na/H Exchanger in Astrogliosis and Early Alzheimer's Disease Pathogenesis.

ABSTRACT: Reactive astrogliosis has been indicated as one of the earliest pathological biomarkers in Alzheimer's Disease (AD) pathology. We previously reported that upregulation of the Na⁺/H⁺ exchanger isoform 1 (NHE1) protein in reactive astrocytes contributes to neuroinflammation and cognitive function deficits in murine models of ischemic stroke and vascular stenosis. In this study, we utilized AD human post-mortem and APP/PS1dE9 (APP) transgenic mouse brain tissues to determine whether NHE1 upregulation in astrocytes is associated with AD pathogenesis. In both AD human and APP mouse brain tissues, a significant elevation of NHE1 protein expression was detected in glial fibrillary acidic protein expressing (GFAP⁺) reactive astrocytes in cortical and hippocampal re

SUBMITTER: Collier JM 

PROVIDER: S-EPMC12539526 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature