Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function.

ABSTRACT: Axons are crucial for transmitting neurochemical signals. As organisms age, the ability of neurons to maintain their axons declines; hence, aged axons are more susceptible to damage or dysfunction. Understanding how aging causes axonal vulnerability is crucial for developing strategies to enhance overall resilience of neurons and prevent neuronal deterioration during aging and in age-related neurodegenerative diseases. Increasing levels of reactive oxygen species (ROS) causes oxidative stress - a hallmark of aging and age-related diseases. Despite this association, a causal relationship between oxidative stress and neuronal aging remains unclear, particularly in how subcellular physiology may be affected by ROS. By using Drosophila-derived primary neuronal cultures and a recently developed

SUBMITTER: Shields S 

PROVIDER: S-EPMC12539546 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature