Identification of peripheral biomarkers through metabolomic analysis in patients with bipolar disorder treated with mood stabilizers: an exploratory study.

ABSTRACT:

Importance

Bipolar disorder (BD) is mainly treated with mood stabilizers, among which lithium represents the gold standard. Despite its high clinical efficacy, the molecular players involved in lithium response and nonresponse remain partly unclear. Therefore, the identification of peripheral biomarkers would significantly improve the management of pharmacological interventions in BD.

Objective and design

In this study, we sought to investigate the blood metabolome in patients with BD to identify biosignatures of treatment with different mood stabilizers as well as possible biomarkers of response to lithium.

Setting and participants

The blood metabolome was measured in a sample of 89 patients with BD either under prophylactic lithium treatment (n = 47), and characteri

SUBMITTER: Piras C 

PROVIDER: S-EPMC12539573 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature