Pharmacokinetics of Double-Layer Patches With Microneedles Containing Procyclidine and Rivastigmine in Guinea Pigs.

ABSTRACT: Reversible cholinesterase inhibitors have been investigated to address prophylactic and therapeutic outcomes against organophosphorus nerve poisoning, and procyclidine is concomitantly used to compensate for their adverse effects. We designed double-layer patches with microneedles composed of a cream layer for immediate release and a hyaluronic acid-based thin solid layer for sustained release. Rivastigmine and procyclidine were added to the two layers with different doses, and their transdermal absorption was explored in guinea pigs for the first time. The contents of hyaluronic acid and the number of microneedles were also examined to determine the optimal patches, which would achieve the mean target plasma concentrations of the two drugs for 72 h. Plasma concentrations of rivastigmine a

SUBMITTER: Moon M 

PROVIDER: S-EPMC12539612 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature